Overview:

Addy™ Focus Stimulant is a dietary supplement blend for men and women ages 18+ that improves focus and concentration, cognitive abilities and mental clarity.

CLAIMS researched:

Based upon the current information available  Addy™ Focus Stimulan qualifies for our STRONGSCIENCE® Certification Mark for the following composite claims:

• Improves focus and concentration
• Improves cognitive abilities
• Improves mental clarity

SUPPLEMENT FACTS:

Ingredient List:

STRONGSCIENCE® RESEARCH TRANSPARENCY

WGCP (Coffea Arabica)

1. Natural Medicines Comprehensive Database http://naturaldatabase.therapeuticresearch.com/ ; last updated on 10/04/2018.
2. Examine.com. Dietary Supplement Guide. https://examine.com/supplements/; as of 10/10/2018
3. Kozuma K, Tsuchiya S, Kohori J, et al. Antihypertensive effect of green coffee bean extract on mildly hypertensive subjects. Hypertens Res. 2005 Sep;28(9):711-8. View abstract.
4. Watanabe T, Arai Y, Mitsui Y, et al. The blood pressure-lowering effect and safety of chlorogenic acid from green coffee bean extract in essential hypertension. Clin Exp Hypertens 2006;28:439-49. View abstract.
5. Onakpoya I, Terry R, Ernst E. The use of green coffee extract as a weight loss supplement: a systematic review and meta-analysis of randomised clinical trials. Gastroenterol Res Pract 2011;2011. pii: 382852. Epub 2010 Aug 31. View abstract.
6. Thom E. The effect of chlorogenic acid enriched coffee on glucose absorption in healthy volunteers and its effect on body mass when used long-term in overweight and obese people. J Int Med Res 2007;35:900-8. View abstract.
7. Dellalibera O, Lemaire B, Lafay S. Svetol, green coffee extract, induces weight loss and increases the lean to fat mass ratio in volunteers with overweight problem. Phytotherapie 2006;4:194-7.
8. Vinson JA, Burnham BR, Nagendran MV. Randomized, double-blind, placebo-controlled, linear dose, crossover study to evaluate the efficacy and safety of a green coffee bean extract in overweight subjects. Diabetes Metab Syndr Obes 2012;5:21-7. View abstract.
9. Michael J. Manos, Craig A. Sidol, Alicia Monaco, Thomas W. Frazier. Preliminary Findings for the Effectiveness of Whole Green Coffee Powder (WGCP) versus Placebo in a Double-blind Withdrawal Design Study with Young Adults on Three Tasks of Executive Function. Clinical Medicine Insights: Psychiatry, 2014:5 1-8; paper at http://journals.sagepub.com/doi/10.4137/CMPsy.S13117

1. Durlach PJ. The effects of a low dose of caffeine on cognitive performance. Psychopharmacology (Berl) 1998;140:116-9. View abstract.
2. Hindmarch I, Quinlan PT, Moore KL, Parkin C. The effects of black tea and other beverages on aspects of cognition and psychomotor performance. Psychopharmacol 1998;139:230-8. View abstract.
3. Haskell, C. F., Kennedy, D. O., Milne, A. L., Wesnes, K. A., and Scholey, A. B. The effects of L-theanine, caffeine and their combination on cognition and mood. Biol.Psychol. 2008;77(2):113-122. View abstract.
4. Peeling, P. and Dawson, B. Influence of caffeine ingestion on perceived mood states, concentration, and arousal levels during a 75-min university lecture. Adv.Physiol Educ. 2007;31(4):332-335. View abstract.
5. Michael, N., Johns, M., Owen, C., and Patterson, J. Effects of caffeine on alertness as measured by infrared reflectance oculography. Psychopharmacology (Berl) 2008;200(2):255-260. View abstract.
6. Mednick, S. C., Cai, D. J., Kanady, J., and Drummond, S. P. Comparing the benefits of caffeine, naps and placebo on verbal, motor and perceptual memory. Behav Brain Res 11-3-2008;193(1):79-86. View abstract.
7. Adan, A. and Serra-Grabulosa, J. M. Effects of caffeine and glucose, alone and combined, on cognitive performance. Hum Psychopharmacol. 2010;25(4):310-317. View abstract.
8. Olson, C. A., Thornton, J. A., Adam, G. E., and Lieberman, H. R. Effects of 2 adenosine antagonists, quercetin and caffeine, on vigilance and mood. J Clin Psychopharmacol. 2010;30(5):573-578. View abstract.
9. Brunye, T. T., Mahoney, C. R., Lieberman, H. R., Giles, G. E., and Taylor, H. A. Acute caffeine consumption enhances the executive control of visual attention in habitual consumers. Brain Cogn 2010;74(3):186-192. View abstract.
10. Dawkins, L., Shahzad, F. Z., Ahmed, S. S., and Edmonds, C. J. Expectation of having consumed caffeine can improve performance and mood. Appetite 2011;57(3):597-600. View abstract.
11. Young HA, Benton D. Caffeine can decrease subjective energy depending on the vehicle with which it is consumed and when it is measured. Psychopharmacology (Berl). 2013 Jul;228(2):243-54. doi: 10.1007/s00213-013-3025-9. Epub 2013 2. View abstract.
12. Ronen A, Oron-Gilad T, Gershon P. The combination of short rest and energy drink consumption as fatigue countermeasures during a prolonged drive of professional truck drivers. J Safety Res. 2014 Jun;49:39-43. doi: 10.1016/j.jsr.2014.02.006. Epub 2014 24. View abstract.
13. Rogers PJ, Heatherley SV, Mullings EL, Smith JE. Faster but not smarter: effects of caffeine and caffeine withdrawal on alertness and performance. Psychopharmacology (Berl). 2013 Mar;226(2):229-40. doi: 10.1007/s00213-012-2889-4. Epub 2012 30. View abstract.
14. 10205Kamimori GH, Penetar DM, Headley DB, et al. Effect of three caffeine doses on plasma catecholamines and alertness during prolonged wakefulness. Eur J Clin Pharmacol 2000;56:537-44.. View abstract.
15. 37716Lohi, J. J., Huttunen, K. H., Lahtinen, T. M., Kilpelainen, A. A., Muhli, A. A., and Leino, T. K. Effect of caffeine on simulator flight performance in sleep-deprived military pilot students. Mil.Med 2007;172(9):982-987. View abstract
16. Killgore, W. D., Rupp, T. L., Grugle, N. L., Reichardt, R. M., Lipizzi, E. L., and Balkin, T. J. Effects of dextroamphetamine, caffeine and modafinil on psychomotor vigilance test performance after 44 h of continuous wakefulness. J Sleep Res 2008;17(3):309-321. View abstract.
17. Killgore, W. D., Kahn-Greene, E. T., Grugle, N. L., Killgore, D. B., and Balkin, T. J. Sustaining executive functions during sleep deprivation: A comparison of caffeine, dextroamphetamine, and modafinil. Sleep 2-1-2009;32(2):205-216. View abstract.
18. Ker, K., Edwards, P. J., Felix, L. M., Blackhall, K., and Roberts, I. Caffeine for the prevention of injuries and errors in shift workers. Cochrane.Database.Syst.Rev. 2010;(5):CD008508. View abstract.
19. Adan, A. and Serra-Grabulosa, J. M. Effects of caffeine and glucose, alone and combined, on cognitive performance. Hum Psychopharmacol. 2010;25(4):310-317. View abstract.
20. 38035Gevins, A., Smith, M. E., McEvoy, L. K., Ilan, A. B., Chan, C. S., Jiang, A., Sam-Vargas, L., and Abraham, G. A cognitive and neurophysiological test of change from an individual’s baseline. Clin.Neurophysiol. 2011;122(1):114-120. View abstract.
21. Serra-Grabulosa, J. M., Adan, A., Falcon, C., and Bargallo, N. Glucose and caffeine effects on sustained attention: an exploratory fMRI study. Hum.Psychopharmacol. 2010;25(7-8):543-552. View abstract.
22. Hartley SL, Barbot F, Machou M, Lejaille M, Moreau B, Vaugier I, Lofaso F, Quera-Salva MA. Combined caffeine and bright light reduces dangerous driving in sleep-deprived healthy volunteers: a pilot cross-over randomised controlled trial. Neurophysiol Clin. 2013;43(3):161-9. doi: 10.1016/j.neucli.2013.04.001. Epub 2013 26. View abstract.
23. Reyner LA, Horne JA. Sleep restriction and serving accuracy in performance tennis players, and effects ofcaffeine. Physiol Behav. 2013 Aug 15;120:93-6. doi: 10.1016/j.physbeh.2013.07.002. Epub 2013 31. View abstract.

1. Capek, S. and Guenther, R. K. Caffeine’s effects on true and false memory. Psychol.Rep. 2009;104(3):787-795. View abstract.
2. Smillie, L. D. and Gokcen, E. Caffeine enhances working memory for extraverts. Biol Psychol. 2010;85(3):496-498. View abstract.
3. Smith AP. Caffeine, extraversion and working memory. J Psychopharmacol. 2013 ;27(1):71-6. doi: 10.1177/0269881112460111. Epub 2012 26. View abstract.

36. Sinclair CJ, Geiger JD. Caffeine use in sports. A pharmacological review. J Sports Med Phys Fitness 2000;40:71-9. View abstract

1. Nurminen ML, Niittynen L, Korpela R, Vapaatalo H. Coffee, caffeine and blood pressure: a critical review. Eur J Clin Nutr 1999;53:831-9. View abstract.
2. Kamimori GH, Penetar DM, Headley DB, et al. Effect of three caffeine doses on plasma catecholamines and alertness during prolonged wakefulness. Eur J Clin Pharmacol 2000;56:537-44. View abstract.
3. 2718Migliardi JR, Armellino JJ, Friedman M, et al. Caffeine as an analgesic adjuvant in tension headache. Clin Pharmacol Ther 1994;56:576-86. View abstract.
4. Smith A. Effects of caffeine on human behavior. Food Chem Toxicol 2002;40:1243-55. View abstract.
5. Institute of Medicine. Caffeine for the Sustainment of Mental Task Performance: Formulations for Military Operations. Washington, DC: National Academy Press, 2001. Available at: http://books.nap.edu/books/0309082587/html/index.html.

42. Katsuyoshi Saitou, Ryuji Ochiai, Kazuya Kozuma, Hirotaka Sato, Takashi Koikedav, Noriko Osaki. Effect of Chlorogenic Acids on Cognitive Function: A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients 2018, 10, 1337; doi:10.3390/nu10101337. At https://www.mdpi.com/2072-6643/10/10/1337

1. Farah A, Donangelo CM. Phenolic compounds in coffee. Braz J Plant Physiol 2006;18:23-44
2. Farah A, Monteiro M, Donangelo CM, Lafay S. Chlorogenic acids from green coffee extract are highly bioavailable in humans. J Nutr 2008;138:2309-15. View abstract.
3. Alonso-Salces RM, Serra F, Reniero F, Héberger K. Botanical and geographical characterization of green coffee (Coffea arabica and Coffea canephora): chemometric evaluation of phenolic and methylxanthine contents. J Agric Food Chem 2009;57:4224-35. View abstract.
4. Shimoda H, Seki E, Aitani M. Inhibitory effect of green coffee bean extract on fat accumulation and body weight gain in mice. BMC Complement Altern Med 2006;6:9. View abstract.
5. Johnston KL, Clifford MN, Morgan LM. Coffee acutely modifies gastrointestinal hormone secretion and glucose tolerance in humans: glycemic effects of chlorogenic acid and caffeine. Am J Clin Nutr. 2003 Oct;78:728-33. View abstract.
6. Ochiai R, Jokura H, Suzuki A, et al. Green coffee bean extract improves human vasoreactivity. Hypertens Res 2004;27:731-7. View abstract.

Amla (Sanskrit Amalaki) 

1. Jacob A, Pandey M, Kapoor S, Saroja R. Effect of the Indian gooseberry (amla) on serum cholesterol levels in men aged 35-55 years. Eur J Clin Nutr 1988;42:939-44. View abstract.
2. Khanna S, Das A, Spieldenner J, Rink C, Roy S. Supplementation of a standardized extract from Phyllanthus emblica improves cardiovascular risk factors and platelet aggregation in overweight/class-1 obese adults. J Med Food. 2015;18(4):415-20.
3. Akhtar MS1, Ramzan A, Ali A, Ahmad M. Effect of Amla fruit (Emblica officinalis Gaertn.) on blood glucose and lipid profile of normal subjects and type 2 diabetic patients. Int J Food Sci Nutr. 2011 Sep;62(6):609-16. doi: 10.3109/09637486.2011.560565
4. Chopra A, Saluja M, Tillu G, Sarmukkaddam S, Venugopalan A, Narsimulu G, Handa R, Sumantran V, Raut A, Bichile L, Joshi K, Patwardhan B. Ayurvedic medicine offers a good alternative to glucosamine and celecoxib in the treatment of symptomatic knee osteoarthritis: a randomized, double-blind, controlled equivalence drug trial. Rheumatology (Oxford) 2013;52(8):1408-17. View abstract.
5. Colucci R, Dragoni F, Conti R, Pisaneschi L, Lazzeri L, Moretti S. Evaluation of an oral supplement containing Phyllanthus emblica fruit extracts, vitamin E, and carotenoids in vitiligo treatment. Dermatol Ther. 2015;28(1):17-21. View abstract.
6. Vasudevan M, Parle M. Memory enhancing activity of Anwala churna (Emblica officinalis Gaertn.): an Ayurvedic preparation. Physiol Behav. 2007 May 16;91(1):46-54
7. Golechha M, Bhatia J, Arya DS. Studies on effects of Emblica officinalis (Amla) on oxidative stress and cholinergic function in scopolamine induced amnesia in mice. J Environ Biol. (2012)
8. Dev S. Ancient-modern concordance in Ayurvedic plants: some examples. Environ Health Perspect 1999;107:783-2077 2077 57. View abstract
9. Asmawi MZ, Kankaanranta H, Moilanen E, Vapaatalo H. Anti-inflammatory activities of Emblica officinalis Gaertn leaf extracts. J Pharm Pharmacol 1993;45:581-4. View abstract.
10. Ihantola-Vormisto A, Summanen J, Kankaanranta H, et al. Anti-inflammatory activity of extracts from leaves of Phyllanthus emblica. Planta Med 1997;63:518-24. View abstract.
11. 8180 58. Anila L, Vijayalakshmi NR. Beneficial effects of flavonoids from Sesamum indicum, Emblica officinalis and Momordica charantia. Phytother Res 2000;14:592-5. View abstract
12. Hu JF. [Inhibitory effects of Phyllanthus emblica juice on formation of N-nitrosomorpholine in vitro and N-nitrosoproline in rat and human]. Chung Hua Yu Fang I Hsueh Tsa Chih 1990;24:132-5. View abstract.
13. Bhattacharya A, Chatterjee A, Ghosal S, Bhattacharya SK. Antioxidant activity of active tannoid principles of Emblica officinalis (amla). Indian J Exp Biol 1999;37:676-80. View abstract.
14. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
15. Dev S. Ancient-modern concordance in Ayurvedic plants: some examples. Environ Health Perspect 1999;107:783-9. View abstract.

 Brahmi (Bacopa) 

1. Kidd PM. A review of nutrients and botanicals in the integrative management of cognitive dysfunction. Altern Med Rev 1999;4:144-61 View abstract.
2. Roodenrys S, et al. Chronic effects of Brahmi (Bacopa monnieri) on human memory.Neuropsychopharmacology. (2002)
3. Stough C, et al. The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects. Psychopharmacology (Berl). (2001)
4. Morgan A, Stevens J. Does Bacopa monnieri improve memory performance in older persons? Results of a randomized, placebo-controlled, double-blind trial. J Altern Complement Med. (2010)
5. Stough C, et al. Examining the nootropic effects of a special extract of Bacopa monniera on human cognitive functioning: 90 day double-blind placebo-controlled randomized trial.Phytother Res. (2008)
6. Raghav S, et al. Randomized controlled trial of standardized Bacopa monniera extract in age-associated memory impairment. Indian J Psychiatry. (2006)
7. Katz M, et al. A compound herbal preparation (CHP) in the treatment of children with ADHD: a randomized controlled trial. J Atten Disord. (2010)
8. Nathan PJ, et al. Effects of a combined extract of Ginkgo biloba and Bacopa monniera on cognitive function in healthy humans. Hum Psychopharmacol. (2004)
9. Maher BF, et al. The acute effects of combined administration of Ginkgo biloba and Bacopa monniera on cognitive function in humans. Hum Psychopharmacol. (2002)
10. Nathan PJ, et al. The acute effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy normal subjects. Hum Psychopharmacol. (2001)
11. Pase MP, et al. The cognitive-enhancing effects of Bacopa monnieri: a systematic review of randomized, controlled human clinical trials. J Altern Complement Med. (2012)
12. Rajan KE, et al. Attenuation of 1-(m-chlorophenyl)-biguanide induced hippocampus-dependent memory impairment by a standardised extract of Bacopa monniera (BESEB CDRI-08).Neurochem Res. (2011)
13. Saraf MK, et al. Bacopa monniera Attenuates Scopolamine-Induced Impairment of Spatial Memory in Mice. Evid Based Complement Alternat Med. (2011)
14. 40 76Kishore K, Singh M. Effect of bacosides, alcoholic extract of Bacopa monniera Linn. (brahmi), on experimental amnesia in mice. Indian J Exp Biol. (2005)
15. Prabhakar S, et al. Bacopa monniera exerts antiamnesic effect on diazepam-induced anterograde amnesia in mice. Psychopharmacology (Berl). (2008)
16. Effect of Bacopa monniera on animal models of Alzheimer’s disease and perturbed central cholinergic markers of cognition in rats.
17. Saraf MK, Prabhakar S, Anand A. Bacopa monniera alleviates N(omega)-nitro-L-arginine arginine-induced but not MK-801-induced amnesia: a mouse Morris watermaze study.Neuroscience. (2009)
18. Kongkeaw C, Dilokthornsakul P, Thanarangsarit P, et al. Meta-analysis of randomized controlled trials on cognitive effects of Bacopa monnieri extract. J Ethnopharmacol 2014;151(1):528-35. View abstract
19. Sathyanarayanan V, et al. Brahmi for the better? New findings challenging cognition and anti-anxiety effects of Brahmi (Bacopa monniera) in healthy adults. Psychopharmacology (Berl). (2013)
20. Singh, R. H. and Singh, L. Studies on the Anti-Anxiety Effect of the Medhya Rasayana Drug, Brahmi (Bacopa monniera Wettst.) – Part I. Journal of Research in Ayurveda and Siddha 1980;1(1):133-148
21. Dave UP, Dingankar SR, Saxena VS, et al. An open-label study to elucidate the effects of standardized Bacopa monnieri extract in the management of symptoms of attention-deficit hyperactivity disorder in children. Adv Mind Body Med 2014;28(2):10-5. View abstract
22. Samiulla DS, Prashanth D, Amit A. Mast cell stabilising activity of Bacopa monnieri. Fitoterapia 2001;72:284-5. View abstract.
23. Kidd PM. A review of nutrients and botanicals in the integrative management of cognitive dysfunction. Altern Med Rev 1999;4:144-61.. View abstract.
24. Stough C, Lloyd J, Clarke J, et al. The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects. Psychopharmacology 2001;156:481-4.. View abstract.
25. Morgan A, Stevens J. Does Bacopa monnieri improve memory performance in older persons? Results of a randomized, placebo-controlled, double-blind trial. J Altern Complement Med 2010;16:753-9. View abstract.
26. Charles PD1, Ambigapathy G, Geraldine P, Akbarsha MA, Rajan KE.Bacopa monniera leaf extract up-regulates tryptophan hydroxylase (TPH2) and serotonin transporter (SERT) expression: implications in memory formation. J Ethnopharmacol. 2011 Mar 8;134(1):55-61. doi: 10.1016/j.jep.2010.11.045. Epub 2010 Dec 1.
27. Vollala VR, Upadhya S, Nayak S. Enhanced dendritic arborization of hippocampal CA3 neurons by Bacopa monniera extract treatment in adult rats. Rom J Morphol Embryol. (2011)
28. Vollala VR, Upadhya S, Nayak S. Enhancement of basolateral amygdaloid neuronal dendritic arborization following Bacopa monniera extract treatment in adult rats. Clinics (Sao Paulo). (2011)
29. Vollala VR, Upadhya S, Nayak S. Enhanced dendritic arborization of amygdala neurons during growth spurt periods in rats orally intubated with Bacopa monniera extract. Anat Sci Int. (2011)
30. Limpeanchob N, Jaipan S, Rattanakaruna S, et al. Neuroprotective effect of Bacopa monnieri on beta-amyloid-induced cell death in primary cortical culture. J Ethnopharmacol 2008;120:112-7. View abstract.
31. Singh M, Murthy V, Ramassamy C. Modulation of hydrogen peroxide and acrolein-induced oxidative stress, mitochondrial dysfunctions and redox regulated pathways by the Bacopa monniera extract: potential implication in Alzheimer’s disease. J Alzheimers Dis 2010;21:229-47. View abstract.
32. Uabundit N, Wattanathorn J, Mucimapura S, Ingkaninan K. Cognitive enhancement and neuroprotective effects of Bacopa monnieri in Alzheimer’s disease model. J Ethnopharmacol 2010;127:26-31. View abstract
33. Yadav SK, Jain AK, Tripathi SN, Gupta JP. Irritable bowel syndrome: therapeutic evaluation of indigenous drugs. Indian J Med Res 1989;90:496-503.. View abstract
34. Morgan A, Stevens J. Does Bacopa monnieri improve memory performance in older persons? Results of a randomized, placebo-controlled, double-blind trial. J Altern Complement Med 2010;16:753-9. View abstract
35. Benson S, Downey LA, Stough C, et al. An acute, double-blind, placebo-controlled cross-over study of 320 mg and 640 mg doses of Bacopa monnieri (CDRI 08) on multitasking stress reactivity and mood. Phytother Res 2014;28(4):551-9. View abstract
36. Downey LA, Kean J, Nemeh F, et al. An acute, double-blind, placebo-controlled crossover study of 320?mg and 640?mg doses of a special extract of Bacopa monnieri (CDRI 08) on sustained cognitive performance. Phytother Res 2013;27(9):1407-13. View abstract.
37. Kongkeaw C, Dilokthornsakul P, Thanarangsarit P, et al. Meta-analysis of randomized controlled trials on cognitive effects of Bacopa monnieri extract. J Ethnopharmacol 2014;151(1):528-35. View abstract.
38. Sharma, R, Chaturvedi, C, and Tewari, PV. Efficacy of Bacopa monniera in revitalizing intellectual functions in children. J Res Edu Ind Med 1987;1-12.

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