KSM-66 Ashwagandha is a branded, full-spectrum extract, with the highest concentration of all major root only extracts available on the market today. It is produced using a unique proprietary extraction process, based on “Green Chemistry” principles, without using alcohol or any other chemical solvent. This proprietary ingredient is used in many products and can be found on the KSM-66 website http://ksm66ashwagandhaa.com/ksm-66/products-with-ksm-66/

Based upon the current information available KSM-66 qualifies for our STRONGSCIENCE® Certification Mark for the following composite claims:

1. Helps to reduce stress and anxiety
2. Helps to promote relaxation
3. Helps to improve the quality of sleep
4. Helps to reduce and maintain normal cortisol levels
5. Helps in the calming-down and relaxation of the body and mind
6. Helps to improve memory
7. Helps to improve learning (adaptation and recognition of systematicities)
8. Helps to improve alertness (rapidity of recognizing changes in stimuli)
9. Helps to improve concentration (the ability to filter out distracting stimuli and increase performance speed)
10. In women, helps to increase sexual arousal, orgasm and satisfaction
11. In men, helps the body to increase and maintain healthy levels of testosterone
12. In men, helps the body to increase sperm concentration and volume^#
13. Helps to boost stamina and endurance
14. Helps to increase muscle size in men
15. Helps to increase muscle strength in men
16. Helps to reduce body fat percentage in men
17. Helps to control stress-related food cravings
18. Helps to reduce and maintain healthy body weight
19. Helps to improve overall body composition when used as part of a healthy diet and exercise program

^# dose used in research was 675mg/d (225mg t.i.d)

Active Ingredients:

KSM-66 Ashwagandha is a branded, full-spectrum extract

Research Transparency™ (Reference List)

1. Natural Medicines Comprehensive Database http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=&s=ND&pt=9&Product=Ashwagandha&btnSearch.x=7&btnSearch.y=10, last updated on 10/31/2017.
2. Bucci LR. Selected herbals and human exercise performance.Am J Clin Nutr 2000 72(suppl):624S–36S.
3. Singh N, Nath R, Lata A, et al. Withania somnifera (ashwagandha), a rejuvenating herbal drug which enhances survival during stress (an adaptogen). Int J Crude Drug Res 1982 20:29-35.
4. Mishra LC, Singh BB, Dagenais S. Scientific basis for the therapeutic use of Withania somnifera (Ashwagandha): A review. Altern Med Rev 20005:334-346.
5. Provino R. The role of adaptogens in stress management. Australian Journal of Medical Herbalism 2010 22: 41-49.
6. Dhuley JN. Adaptogenic and cardioprotective action of Ashwagandha in rats and frogs. J Ethanopharmacol 2000 70: 57-63.
7. Raut AA, Rege NN, Tadvi FM, Solanki PV, Kene KR, Shirolkar SG, Pandey SN, Vaidya RA, Vaidya AB. Exploratory study to evaluate tolerability, safety, and activity of Ashwagandha (Withania somnifera) in healthy volunteers. J Ayur Integrative Med 2012 3: 109-172.
8. Sandhu JS, Shah B, Shenoy S, Chauhan S, Lavekar GS, Padhi MM. Effects of Withania somnifera (Ashwagandha) and Terminalia arjuna (Arjuna) on physical performance and cardiorespiratory endurance in healthy young adults. Int J Ayurveda Res 2010 1:144-149.
9. Zovco Koncic M, Tomczyk, M. New Insights into Dietary Supplements Used in Sport: Active Substances, Pharmacological and Side Effects. Current Drug targets 2013 14:1079-1092.
10. Alam N, Monzur H, Khalil I, Moniruzzaman M, Sulaiman SA,Gan HS. Recent advances in elucidating the biological properties of Withania somnifera and its potential role in health benefits. Phytochem Res Published on line by Springer: DOI 10.1007/s11101-011-9221-5. 2011.http://link.springer.com/article/10.1007/s11101-011-9221-5#page-1
11. Archana R, Namasivayam A. Antistressor effect of Withania somnifera. J Ethnopharmacol 1999 64:91-3. View abstract.
12. Kulkarni SK, Dhir A. Withania somnifera: An Indian ginseng. Progress in Neuro-Psychopharmacology & Biological Psychiatry 2008 32: 1093–1105.
13. Chandrasekhar K, Kapoor J, Anishetty S. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian J Psychol Med 2012 34:255-62.
14. Dongre S. Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Improving Sexual Function in Women: a double‐blind, randomized, placebo‐controlled study.
15. Ambiye VR, Langade D, Dongre S, Aptikar P, Kulkarni M, Dongre A. Clinical Evaluation of the Spermatogenic Activity of the Root Extract of Ashwagandha (Withania somnifera) in Oligospermic Males: A Pilot Study.  Evidence-Based Complementary and Alternative Medicine Volume 2013, Article ID 571420, 6 pages. http://dx.doi.org/10.1155/2013/571420
16. Choudhary B, Shetty A, Langade DG. Efficacy of Ashwagandha (Withania somnifera [L.] Dunal) in improving cardiorespiratory endurance in healthy athletic adults. 2015 36(1):63-8. doi: 10.4103/0974-8520.169002.
17. Chapman, PP, Whitehead JR, Binkkert RH. The 225-lb reps-to fatigue test as a submaximal estimate of 1-RM bench-press performance in college football players. J Strength Con Res 1998 12:258-261.
18. Brzycki M. Strength testing: predicting a one-rep max from repetitions to fatigue. JOPERD 1993 64:88-90.
19. Upton R, ed. Ashwagandha Root (Withania somnifera): Analytical, quality control, and therapeutic monograph. Santa Cruz, CA: American Herbal Pharmacopoeia 2000:1-25.
20. Bhattacharya SK, Satyan KS, Ghosal S. Antioxidant activity of glycowithanolides from Withania somnifera. Indian J Exp Biol 1997;35: 236-9. View abstract.
21. Dasgupta A, Peterson A, Wells A, Actor JK. Effect of Indian Ayurvedic medicine Ashwagandha on measurement of serum digoxin and 11 commonly monitored drugs using immunoassays: study of protein binding and interaction with Digibind. Arch Pathol Lab Med 2007 131: 1298-303. View abstract.
22. Davis L, Kuttan G. Effect of Withania somnifera on cyclophosphamide-induced urotoxicity. Cancer Lett 2000 148:9-17. View abstract.
23. Davis L, Kuttan G. Suppressive effect of cyclophosphamide-induced toxicity by Withania somnifera extract in mice. J Ethnopharmacol 1998 62:209-14. View abstract
24. Cooley K, Szczurko O, Perri D, et al. Naturopathic care for anxiety: a randomized controlled trial ISRC TN78958974. PLoS One 2009 4:e6628. View abstract.
25. Sud Khyati S, Thaker B. A randomized double blind placebo controlled study of ashwagandha on generalized anxiety disorder. Int Ayurvedic Med J 2013 1(5):1-7.
26. Andallu B, Radhika B. 2000. Hypoglycemic, diuretic and hypocholesterolemic effect of winter cherry (Withania somnifera, Dunal) root. Indian J Exp Biol 38:607-9.
27. Choudhary, D., Bhattacharyya, S., Joshi, K., Body Weight Management in Adults Under Chronic Stress through Treatment with Ashwagandha Root Extract: A Double-Blind, Randomized, Placebo-Controlled Trial. Journal of Evidence-Based Complementary & Alternative Medicine. 2016.22 96-106.
28. Wankhede S, Langade, D., Joshi, K., Sinha, S.R., Bhattacharyya, S., “Examining the effects of Withania somnifera supplementation on muscle strength and recovery: a randomized controlled trial”, Journal of the International Society of Sports Nutrition 2015 12:43, 11 pages.
29. Cooley K, Szczurko O, Perri D, et al. Naturopathic care for anxiety: a randomized controlled trial ISRC TN78958974. PLoS One 2009;4:e6628. View abstract.
30. Agnihotri AP, Sontakke SD, Thawani VR, Saoji A, Goswami VS. Effects of Withania somnifera in patients of schizophrenia: a randomized, double blind, placebo controlled pilot trial study. Indian J Pharmacol. 2013 45(4):417-8. View abstract.
31. Chengappa KN, Bowie CR, Schlicht PJ, Fleet D, Brar JS, Jindal R. Randomized placebo-controlled adjunctive study of an extract of withania somnifera for cognitive dysfunction in bipolar disorder. J Clin Psychiatry. 2013 74(11):1076-83. View abstract.
32. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association’s Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
33. Choudhary, D., Bhattacharyya, S., & Bose, S. (2017). and Safety of Ashwagandha (Withania somnifera (L.) Dunal) Root Extract in Improving Memory and Cognitive Functions. Journal of Dietary Supplements, 1-14. Chicago Efficacy
34. Sharma, A. K., Basu, I., & Singh, S. (2017). Efficacy and Safety of Ashwagandha Root Extract in Subclinical Hypothyroid Patients: A Double-Blind, Randomized Placebo-Controlled Trial. The Journal of Alternative and Complementary Medicine.
35. Kumar, R., Gupta, K., Saharia, K., Pradhan, D., & Subramaniam, J. R. (2013). Withania somnifera root extract extends lifespan of Caenorhabditis elegans. Annals of neurosciences, 20(1), 13.
36. Raguraman, V., & Subramaniam, J. R. (2016). Withania somnifera Root Extract Enhances Telomerase Activity in the Human HeLa Cell Line.  Advances in Bioscience and Biotechnology, 7(04), 199.
37. https://health-products.canada.ca/lnhpd-bdpsnh/info.do?licence=80047973 

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